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PAI-1 (Elevated Plasminogen Activators)

JourneytoJoy07JourneytoJoy07 member
in Infertility
After having a recurrent miscarriage panel done, it was found that I had elevated plasminogen activators, which is also known as PAI-1.  Mine was a 64. Normal range is 4-43.   Has anyone else been diagnosed with this?  I have an appointment with a hematologist in a few months and was hoping to find others in my situation!  

Me:28, DH:30 Married: 07/07/07 TTC Since: March 2011 MFI Me: Possible PAI-1
April 2012:Varicocele embolization
IVF #1 July 2012: BFN :( DH- Femara 90 days 
12/10/2012 Femara helped!
IVF# 2: Jan 2013 BFP, M/C 6weeks0days
5 frosties. 
IVF #3 FET April 2013 BFP, M/C 7 weeks 0 days. 
3 frosties
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Re: PAI-1 (Elevated Plasminogen Activators)

  • MargritliMargritli member
    I can't answer your question, but I just wanted to say that I am really sorry for your losses. Hopefully, there is someone on here who might be able to give you some insight.

    Me: 28, DH: 35
    DX: Severe MFI, AZFc Microdeletion
    TTC since August 2011
    IVF w/ ICSI 1: Dec. 2013 - BFN
    FET 1.2: Mar. 2014 - BFN
    FET 1.3: May 2014 - BFN
    FET 1.4: June 2014 - BFP
    Two little buns in the oven. 
    Bake until March 2015, little ones. 


    "Life will be clearer around me.
     Life will be more burdensome for me. 
    Life will be richer for me." 
    -Rudolf Steiner
    Report Reply
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  • RosyGlowRosyGlow member
    Hi. It's good to see you again. I am glad to hear you found a new DX that may lead to some answers. I have seen gals post about this before, but I can't remember who it was. I hope some of them speak up. I hope there will be some great options for you...good luck.
    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


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  • liz4pawsliz4paws member
    How soon after your loss was the test done? I had this same thing happen to me but it turns out it's because pregnancy can increase this level. I had it redrawn about 4 weeks later and it went to normal levels. Good luck!

    ************ Signature/Ticker Warning ************
     Me (32) DH (36) - Finding our way to baby #1
     Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
     DH: Severe MFI

     12/2/11 - IUI #1- BFN 
    8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)
    My ovaries are just for decoration

     12/6/12 - Adopted five embryos that had been frozen for over ten years!
     2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts. 
     2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
     3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.

    6/5/13 - Adopted four new embryos that had been frozen for seven years!      
    9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
    9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
     9/29/13 - m/c @ 5w1d. :(

    11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
     11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
    Beta #1 @ 13dp6dt - 522  Beta #2 @ 16dp6dt - 1373 
    6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!

    Snowflake baby is a girl! 
    Our beautiful Snowflake girl arrived on July 22, 2014!   
     My embryo adoption blog: Wishing on a Snowflake
      
        image      image 
    Report Reply
  • JourneytoJoy07JourneytoJoy07 member
    @liz4paws it was 4.5 weeks after the miscarriage.  How far apart was your bloodwork from miscarriage?
    Me:28, DH:30 Married: 07/07/07 TTC Since: March 2011 MFI Me: Possible PAI-1
    April 2012:Varicocele embolization
    IVF #1 July 2012: BFN :( DH- Femara 90 days 
    12/10/2012 Femara helped!
    IVF# 2: Jan 2013 BFP, M/C 6weeks0days
    5 frosties. 
    IVF #3 FET April 2013 BFP, M/C 7 weeks 0 days. 
    3 frosties
    Report Reply
  • liz4pawsliz4paws member
    @JourneytoJoy07 I don't remember completely, but I think it was three or four weeks after. Before you get too worried about it, it may be pregnancy related. You may ask for a redraw in a couple of weeks. Good luck!

    ************ Signature/Ticker Warning ************
     Me (32) DH (36) - Finding our way to baby #1
     Me: POF/DOR - AMH <0.16, heterozygous c677t MTHFR, insulin resistant and gluten intolerant
     DH: Severe MFI

     12/2/11 - IUI #1- BFN 
    8/1/12 - IVF #1 - Zero response from max stims (600iu intramuscularly)
    My ovaries are just for decoration

     12/6/12 - Adopted five embryos that had been frozen for over ten years!
     2/11/13 - DEmbryo FET #1 Thawed four, sadly two didn't survive. Transferred two beautiful blasts. 
     2/16/13 - First BFP of my life @ 6dp5dt! EDD 10/30/13
     3/27/13 - After beta and u/s hell, no heartbeat ever detected. D&C at 9w1d.

    6/5/13 - Adopted four new embryos that had been frozen for seven years!      
    9/12/13 - DEmbryo FET #2. Thawed and transferred two beautiful blasts
    9/17/13 - BFP @ 5dp6dt! EDD 05/31/14
     9/29/13 - m/c @ 5w1d. :(

    11/19/13 - DEmbryo FET #3. Thawed and transferred one blast from each batch. Wow!
     11/23/13 - BFP @ 4dp6dt! EDD 8/7/13
    Beta #1 @ 13dp6dt - 522  Beta #2 @ 16dp6dt - 1373 
    6w5d ultrasound showed one perfect baby with a beautiful heartbeat of 134bpm!

    Snowflake baby is a girl! 
    Our beautiful Snowflake girl arrived on July 22, 2014!   
     My embryo adoption blog: Wishing on a Snowflake
      
        image      image 
    Report Reply
  • WindyCity33WindyCity33 member
    I second Liz...I replied to your post on IFV before I saw this one.

    Unmedicated and medicated IUI's: all fail
    IVF #1: Dec 2012 16m/15f 12/9: 5dt of 2 beautiful blasts and 5 frosties
    TWINS!
    15w4d:baby a-pProm
    March 25: 18w...2 baby boys born sleeping
    July 29: FET-BFN

    Sept: TAC placed

    Oct 27: FET #2-Cancelled-monster cyst producing insane amounts of estrogen

    Nov 13: FET #2-take 2
    imageimage

    Report Reply
  • megs3084megs3084 member
    I did the same as windy! Also, I got put on a low carb diet.
    "Everything will be alright in the end. So if it's not alright, it is not yet the end."
    Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
    Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
    8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
    ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
    IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
    ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
    3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
    DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
    7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
    (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
    ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
    ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
    Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
    11/11: TEAM PURPLE!!!!!
    3/21/14-L&W born at 37w via csection
    Here Comes the Sun Blog
    PAIF/SAIF welcome!
    Report Reply
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