Infertility
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Ganirelix?

CallaLily30CallaLily30 member
edited January 2014 in Infertility

So I'm hoping some of the veterans here will be able to help me out with some Ganirelix questions.  Yesterday, I had a monitoring ultrasound and I have two follicles on one side measuring 11mm and 16 less than 10mm on both sides. 

My nurse had me add the ganirelix yesterday but I only have 4 prefilled syringes so I assume that most people only take it for 4 days.  Does that sound right?  I was anticipating my egg retrieval would be between 11-14 January which isn't until Saturday (more than 3 days away).

ETA: Yesterday was day 6 of stims for me.

 image

BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

FET #1 - March 26, BFN

FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

FET#3 - February 1, 2015, Prep begins 1/13

All Welcome!

Re: Ganirelix?

  • Options
    I'm a poor responder so on my last cycle, I started on day 9 of stims and needed 7 ( I stimmed for 14.5 days). You'll stop on when you stop stims.
    ****************SIGGY WARNING****************

    image
    TTC since 2011
    DH: 29, Severe MFI; grade III varicocele; surgery postponed till KU
    Me: 30, POF/DOR, factor II hetero, MTHFR homo
    5 IVF's, LLP, EEP, MDLF all BFN
    IVF 6 using DEB USA frozen eggs
    developed bilateral PE's from BCP, cancelled/delayed 6 mths, taking lovenox
    Feb'15 SURPRISE 1st BFP ever! EDD: 10/10/15, FX
    Still have frozen donor eggs on ice
    All are welcome!
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    I am currently on Lupron for down regulation, but will start ganirelix Thursday, the day of my baseline. Many women on here don't start taking it until after they start stimming.

     I took ganirelix for 14 days last cycle. Ganirelix is usually taken one of two ways, either the entire ppre-filled syringe or by splitting the syringe and taking a half dose.

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

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    For my IVF cycle I used five ganirelix doses (full needle). Then for my FET immediately after I used it for something like nine days to fully suppress an ovulation. There is a high chance you'll need to order more. Talk to your REs office to see if they think you'll need more.

    TTC since July 2009. Dx MFI & LPD. 
    IUI#1&2&3 (2011 & 2012) BFN
    IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
    IUI#5 BFN (April 2013)
    IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
    BFP! Beta 1:104 @ 10dp6dt, Beta 2:178 @ 12dp6dt,  beta 3:366 @ 14dp6dt
    Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
    JUNE 2014 IVF#2;  5R, 2M, 1F Three day transfer 6/7.  Beta 6/18 - BFN
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  • Options
    I had ganirelix added in on day 5 of stims last time.  Not sure what my follie sizes were cause the system isn't working at the moment.  But they had only ordered me 5 of them and on the morning of day 10 I went in for monitoring and had to get an extra from the office in case I needed to do another that night....once it was added in I had to keep taking it till it was time to trigger.  I actually ended up triggering that night instead and gave it back to them...but I did almost not have enough.  Hopefully they have an emergency stash in your office as well???
    image
    Me: 36, unexplained 
    Him: 36, slightly low count 
    TTC since May 2011 
    IUI #1 w/Clomid - 10/2012 BFN 
    Break for cysts 
    IUI #2 w/Clomid - 12/2012 BFN 
    Break for cysts 
    IUI #3 w/Clomid - 2/2013 BFN 
    Break for sanity and to work on health with diet, exercise, and acupuncture 
    IVF/ICSI #1 - BCP, 150 Follistim, 150 Menopur, and Ganirelix
    Retrieval 9/11/2013 - 31 eggs, 17 fertilized, 3 blasts frozen 
    Transfer cancelled - Moderate OHSS 
    FET #1 - 10/22/2013 Transferred 2 (1 did not survive thaw) BFP resulted in CP 
    IVF/ICSI #2 - EPP - Starting stims 1/5/2014 (100 Follistim, 150 Menopur)
    All welcome!


    image
  • Options
    I started the ganirelix as soon as I had a follicle at 12 and used it for 5 days. I only had 5 doses and the nurse ordered me more on day 4 just to be safe. I would really think they have a few emergency doses on hand.
    Me: 30 DH: 30 ~ TTC #1 Since August 2011 
    BFP #1 2/28/13, Ectopic, Tubal surgery 3/25 
    Began RE testing 8/8, Dx Unexplained, 
    IUI #1 11/1=BFN Moving on to IVF 
    IVF #1 12/2 ER 8R 7M 4 fertilized
    12/7 Transferred 2 "perfect" little blasts 12/17 BFN
    New DX= DOR, I fu*kng hate IF
    1/14 Hysteroscopy, new clean uterus!
    IVF #2: bcp, Lupron, follistim 300, menopur 225. 2/21 8R 4M 3F. 3dt of 2 perfect embryos. 1 little penguin 
     3/10 BFFN
    Regrouping. Seeing reproductive immunologist Dr. Kwak Kim 6/10 
    Kwak Kim protocol: Metformin 1000mg, vitamin D 4000iu, vitamin E 400iu, baby aspirin, Metanx, levothyroxine 75mcgs 
     Surprise BFP 9/21!!! Beta #1 247, Beta #2 630. Miscarried 10/13

  • Options
    I did Ganirelix for 3 days before starting stims and then I'll start it again everyday once my follies are large enough until trigger.  I started with 11 doses.  I would guess that you are probably going to need more.
    TTC #1 Since May 2011 ~ Everyone Welcome
    Me (34): DOR d/t chemo/radiation, Immature Endometrial Lining, Hypothyroidism
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    Sept '11-April '13 ~  Testing, failed multiple MFI treatments, saving & TONS of praying
    January 2014 ~ IVF/ICSI & PGS ~ no response to stims ~ converted to IUI ~ BFN
    February 2014 ~ On to donor embyros ~ 5 blasts!!! 
    March 2014 ~ FET #1 ~ Transferred 2 blasts ~ BFN
    July 2014 ~ Kliman's mock cycle with endometrial function test
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    @missmarypoppins Thanks so much for your response.  My follicles were at 11 yesterday I was worried about using the Ganirelex too early.

    If I have to buy more, I have to buy more.  The cost for the meds is insignificant related to the cost of the cycle.

     image

    BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

    2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

    IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

    IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

    FET #1 - March 26, BFN

    FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

    IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

    FET#3 - February 1, 2015, Prep begins 1/13

    All Welcome!

  • Options
    Sunny BSunny B member
    edited January 2014

    They only wrote me a prescription for 5 syringes of Ganirelix, and ended up giving me a refill. I took it for 7 days total. ETA: They started me on it of Day 6 of stimming, and all of my follicles were under 10mm.

    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
  • Options

    @Sunny B thanks for the response...  Most posts I read online had people start taking it when they already had follicles at 14 or so. I was getting worried I was starting too early.

     image

    BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

    2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

    IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

    IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

    FET #1 - March 26, BFN

    FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

    IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

    FET#3 - February 1, 2015, Prep begins 1/13

    All Welcome!

  • Options

    @Sunny B thanks for the response...  Most posts I read online had people start taking it when they already had follicles at 14 or so. I was getting worried I was starting too early.


    My RE basically bumped up my Gonal F the day he started Ganirelix, so I think he did it preventatively, because he wasn't sure how the increase in meds would impact things and he didn't want me to ovulate!!!
    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
  • Options
    Sunny BSunny B member
    edited January 2014

    Also, from what I read at the time, it is pretty common to start Ganirelix on Day 6 regardless.

     

    And if this helps- I stimmed for 11 days, trigger on Day 11, and ER on Day 13. My follicles were all around 16-18 at that time. I had a big jump days 8-10.

    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
  • Options

     

    Sunny B said:

    Also, from what I read at the time, it is pretty common to start Ganirelix on Day 6 regardless.

     

    And if this helps- I stimmed for 11 days, trigger on Day 11, and ER on Day 13. My follicles were all around 16-18 at that time. I had a big jump days 8-10.


    Thanks so much for the info!  I'm so stressed about my follicles and whether or not we will get any "normal" embryos.

     image

    BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

    2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

    IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

    IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

    FET #1 - March 26, BFN

    FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

    IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

    FET#3 - February 1, 2015, Prep begins 1/13

    All Welcome!

  • Options

    It's not letting me edit- and I wanted to put a mm after 16-18.

    I wanted to add something else. It seems like we have a lot of similarities. They retrieved 18 from me and it sounds like were at similar growth on Day 5-6! What's your E2? 

    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
  • Options
    Sunny B said:

    It's not letting me edit- and I wanted to put a mm after 16-18.

    I wanted to add something else. It seems like we have a lot of similarities. They retrieved 18 from me and it sounds like were at similar growth on Day 5-6! What's your E2? 

    E2 was 259 yesterday... I would love to get 18!

     image

    BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

    2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

    IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

    IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

    FET #1 - March 26, BFN

    FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

    IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

    FET#3 - February 1, 2015, Prep begins 1/13

    All Welcome!

  • Options
    Sunny B said:

    It's not letting me edit- and I wanted to put a mm after 16-18.

    I wanted to add something else. It seems like we have a lot of similarities. They retrieved 18 from me and it sounds like were at similar growth on Day 5-6! What's your E2? 

    E2 was 259 yesterday... I would love to get 18!

    I have to check in my handy IVF notebook what exactly mine was (if you're interested!)-- but I know that it was around there! I was a slow riser! I would love if you did too :)
    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
  • Options
    Sunny B said:
    Sunny B said:

    It's not letting me edit- and I wanted to put a mm after 16-18.

    I wanted to add something else. It seems like we have a lot of similarities. They retrieved 18 from me and it sounds like were at similar growth on Day 5-6! What's your E2? 

    E2 was 259 yesterday... I would love to get 18!

    I have to check in my handy IVF notebook what exactly mine was (if you're interested!)-- but I know that it was around there! I was a slow riser! I would love if you did too :)
    Any info you have about your cycle that you don't mind sharing, I'd love to hear!

     image

    BFP #1: 1/4/13, EDD 9/8/13, Missed M/C confirmed 2/8/13, Misoprostol

    2013: Three CPs w/ EDDs: EDD 2/10/14, EDD 3/24/14, EDD 6/24/14

    IVF/ICSI #1 (Antagonist) - Jan 2014- 19R, 14M, 11F, 3 penguins (6BB, 4BB, 6BC)  PGD tested- All Normal!

    IVF/ICSI #2 (Antagonist) - Feb 2014 - 23R, 11M, 10F, 1 penguin (3BB) - Another Normal!

    FET #1 - March 26, BFN

    FET #2- Beta #1 (9dp5dt) -332, Beta #2 (11dp5dt) -1027, EDD 1/30/2015, Missed M/C, D&C 6/19/14

    IVF/ICSI #3 (Lupron Down Reg) - Oct 2014 - 38R, 28M, 27F, 20 frozen on day 5, 16 normal penguins!!

    FET#3 - February 1, 2015, Prep begins 1/13

    All Welcome!

  • Options
    I would say that sounds about right.  They usually start ganirelix when the largest is around 12mm.  Mine was started VERY late because my follies grow fast and not started until the largest was 16mm and I ultimately Oed early. 
    image



    Me 28 DH 30

    After 4+ years TTC

    FET #2 = DS Madden Jeffery <3 July 29, 2014 <3
  • Options
    Sunny B said:
    Sunny B said:

    It's not letting me edit- and I wanted to put a mm after 16-18.

    I wanted to add something else. It seems like we have a lot of similarities. They retrieved 18 from me and it sounds like were at similar growth on Day 5-6! What's your E2? 

    E2 was 259 yesterday... I would love to get 18!

    I have to check in my handy IVF notebook what exactly mine was (if you're interested!)-- but I know that it was around there! I was a slow riser! I would love if you did too :)
    Any info you have about your cycle that you don't mind sharing, I'd love to hear!

    I'll page you when I get home!
    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
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