Community› The Bump Message Boards› TTC After a Loss
TTC After a Loss
New Discussion

PAI-1 and MTHFR?

RunningGal900RunningGal900 member
in TTC After a Loss
I just got the results back that I have the 4g/5g genotype of the the PAI-1. I am also homozygous C677T for the MTHFR mutation. My OB drew my homocysteine levels and it came back normal. She prescribed high dose folic acid and a baby aspirin daily. She said if I had come back 4g/4g she would have recommended blood thinners, but with 4g/5g she does not. I discussed this with my RE and he agreed, no blood thinners. It seems like everything I've read online indicates I should be on blood thinners. Just curious if any of you have both and what protocol your Drs are following. I'm trying to get in with a hematologist, but they won't schedule me until my records are forwarded, so it could be a few days before I know when my appointment might be. 
Warning No formatter is installed for the format bbhtml
Report Reply to Post

Re: PAI-1 and MTHFR?

  • KatieRose09KatieRose09

    I have yet to have my follow up appointment with my RE to get the specifics, but they did call and tell me that they found PAI-1.  The nurse mentioned baby asprin daily and then blood thinner injections once I'm pregnant again.  Right  now I am to avoid taking the asprin because I will be having surgery soon.

     

    TTC our first, both age 29 BFP#1 Twins, Missed MC with complications (long story) BFP#2 CP DX: DH-no issues Me-PAI-1 1/2013 Hysteroscopy/Laparoscopy to remove polyp and adhesions March 2013 IUI #1 with Follitism + Trigger
    Report Reply
  • RunningGal900RunningGal900 member
    Thanks. The hematologist's office just called to say they had a cancellation for tomorrow so I am going to go. Do you know which form of PAI-1 you have? She specifically said with my type she didn't recommend blood thinners, but with another form she would have. 
    Warning No formatter is installed for the format bbhtml
    Report Reply
  • Loading the player...
  • Holly THHolly TH

    R,

    Did he put you on synthetic folic acid?  You have the most severe form of the mutation and have a very limited ability to metabolize synthetic folic acid.  You might want to ask him about active L-methylfolate which bypasses the MTHFR mutation.  Good luck! 

    Married to DH - 1996 DS - 13, DD - 11, DD - 9, DS - 4
    Report Reply
This discussion has been closed.
Choose Another Board
Search Boards
"
"