Trouble TTC

Genetic Testing

Hey ladies - first of all, to the IVF'ers, I am SO sorry that I didn't post the IVF check in today! I am traveling for work and won't be able to post it until I get back on Wednesday. Hope you all don't mind waiting a couple extra days.

 

In other news.....I got a call from my Dr. today re: my genetic testing results. I was shocked to find out that I am a carrier for Cystic Fibrosis. Sad  I didn't even talk to the Dr. because I was on a flight OOT for work, so I just listened to the message. He said that the lab that completed the genetic testing noted a 1 in 110 "reproductive risk." I don't know what this means. I know that we have to get DH tested and I shouldn't stress before that happens, but I can't help but worry a bit.   I have heard that there is only like a 1 in 628 chance of both partners being carriers, so those are pretty low odds, but still, I am in shock. Is anyone else here a carrier?


** After  2 1/2 years of Unexplained IF, 2 failed medicated cycles, and 4 failed IUI's - our baby girl is coming to us through the miracle of Mini IVF! **

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Re: Genetic Testing

  • I'm so sorry GG.  I can't remember if it was someone here or on TTCAL that learned that but then had her husband tested and he was in the clear.  I hope that your husband isn't a carrier and you don't have to worry.  But I agree that those odds seem really low.  

    As for the IVF check in, since it's so new - I couldn't remember what day it was.  Have a safe work trip and we'll all check in when you get back. 


    TTC since July 2009. Dx MFI & LPD. 
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  • I am a carrier too. I was also in shock. I had no clue!!! Luckily DH isn't, but that was a long wait to find out! I ended up letting my brother know so that he could get tested or his wife get tested. I hope your DH isn't a carrier either!! GL! T&P with you!!
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  • image Say1009:
    I am a carrier too. I was also in shock. I had no clue!!! Luckily DH isn't, but that was a long wait to find out! I ended up letting my brother know so that he could get tested or his wife get tested. I hope your DH isn't a carrier either!! GL! T&P with you!!

    Yes! I remember this now, but for some reason I though it was Fragile X - I don't know where I got that from. Hopefully DH can get in soon to get tested. I can imagine the wait to find out will feel like forever. I also let my sisters know - both of my biological sisters are currently pregnant. Hopefully this is really nothing to worry about. The only thing that is stressing me out is that I have a feeling that my IVF might be delayed until his results are in. Sad I guess I'll know more once I actually talk with my Dr's.  Thanks for the T & P's, ladies! 


    ** After  2 1/2 years of Unexplained IF, 2 failed medicated cycles, and 4 failed IUI's - our baby girl is coming to us through the miracle of Mini IVF! **

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  • Sorry GG - I bet that was pretty shocking news. FX that your hubby is not a carrier. Glad the odds are in your favor there. GL!

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    3/2014: Lost our precious Petey due to severe deformities. TFMR at 20weeks PG :-(
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  • I hope you get some answers soon and it doesn't delay your IVF treatment. Keep us posted!

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    Married 10/10/09. Me: 34 DH: 37. Started TTC 02/2012.  Diagnosed with unexplained infertility 5/20/13. 
    Cycle #1 - #15: TTC naturally.
    Cycle #5: BFP. Ended in m/c at 7weeks 5 days.
    Cycle #6-#7: TTA because of believed molar pregnancy. Genetic testing revealed no molar.
    Cycle #8 - #15: TTC naturally.Diagnosed with unexplained infertility during cycle #15.
    Cycle #16: 06/3/13: TI #1 with Clomid (50 mg) + FSH + Trigger. BFN
    Cycle #17: 6/28/13: TI #2 Clomid (50 mg) + FSH + Trigger. BFP 7/24/13!! Beta #1 633 on 7/29/13. Beta #2 1114 on 7/31/13 - not double but nurse said looks good.
  • I am a carrier of CF and was shocked as well.  DH was tested and thankfully he is not a carrier.  For a Caucasian with no family history the odds of being a carrier is about 3% (other ethnicities have even lower odds).  So there is a good chance that your DH is not a carrier, I found these stats helpful during the wait for his test to come back.

    The risk only comes up if both parents are carriers.   Because CF is a recessive mutation, a child must receive the CF gene from both parents to have the disease.  If both parents are carriers, they have a 25% chance of having a child with CF (they have a 50% chance of having a child that is a carrier and a 25% chance of having a non carrier child).  If only one parent is a carrier, they cannot have a child with CF, but have a 50% chance of having a child that is a carrier.  This is important to know because when your children grow up they will probably want to be tested to see if they are a carrier.

    let me know if you ave any more questions.  I did way too much research while waiting for DH's results to come back. :) 

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    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

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  • We haven't had genetic testing done and I don't have any advice for you. I just wanted to say I'm sorry that the results have left you in shock and wondering what it all means.

    Keep us posted on what you find out from your RE. *big hugs* 

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    05.2013 IUI cycle #1 - Clomid - follies 27,22,21,12- 31mil post wash 98% motile - BFN
    06.2013 IUI cycle #2 - Clomid - follies 32,22,18,18,14 - 22mil post wash 99% motile - BFN
    07.2013 IUI cycle #3 -  Clomid - follies 29, 20, 15 - 43mil post wash 98% motile -
    BFN
    08.2013 09.2013 IVF cycle #1 - Lupron + Menopur + Follistim - 7R 6F - 5dt (2) 4AA blasts - BFP on HPT 4dp5dT

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    12dp5dt -
    Beta #2 = 475
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            8w - 166bpm
          10w - 158bpm

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  • image Twinkie0612:

    I am a carrier of CF and was shocked as well.  DH was tested and thankfully he is not a carrier.  For a Caucasian with no family history the odds of being a carrier is about 3% (other ethnicities have even lower odds).  So there is a good chance that your DH is not a carrier, I found these stats helpful during the wait for his test to come back.

    The risk only comes up if both parents are carriers.   Because CF is a recessive mutation, a child must receive the CF gene from both parents to have the disease.  If both parents are carriers, they have a 25% chance of having a child with CF (they have a 50% chance of having a child that is a carrier and a 25% chance of having a non carrier child).  If only one parent is a carrier, they cannot have a child with CF, but have a 50% chance of having a child that is a carrier.  This is important to know because when your children grow up they will probably want to be tested to see if they are a carrier.

    let me know if you ave any more questions.  I did way too much research while waiting for DH's results to come back. :) 

    This is hugely helpful. Thanks so much. I will definitely let you know if I have any questions - I have a feeling I will as I wait for his results to come back.

    Thanks again everyone for the encouragement. :) 


    ** After  2 1/2 years of Unexplained IF, 2 failed medicated cycles, and 4 failed IUI's - our baby girl is coming to us through the miracle of Mini IVF! **

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  • I'm sorry GG. I'm sending lots of positive thoughts your way that YH is not a carrier.
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  • I went through the same thing. When I had surgery in 2010 I am a carrier for CF. So DH got tests and I got retested both of us with the Council test and the company guarantees you will not pay more than 99 oop per person. He came back negative for CF. so our risk for CF is actually now 1 in 3,600. The normal population with both parents negative was 1 in 3,100 according to the Council test people. That test is totally worth it!!! GL!!!

    March 2013: First TTC trip to RE, On 1500 mg Metformin, April 2013:  PCOS and Endometriosis, May 2013:  DH Low volume; Femara 7.5 mg + IUI #1 = BFN, July 2013: Femara 7.5 mg + IUI #2 = BFN, August 2013:  Femara 7.5 mg (X5) + Bravelle (X7) + Ovidrel + IUI #3 + Endometrin = BFP  MC at 5w3d,
    October 2013:  Follistim (X14) + Ovidrel + IUI #4 + Endometrin =BFP!!! 

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  • I'm so sorry GG.  FX for good test results for YH and that your IVF won't be delayed.
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  • I'm so sorry about the shocking news. FX that your DH isn't a carrier. Hugs to you while you wait for answers
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    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
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    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN
    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently Suppressing

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