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My son has been on Zantac for a little over a month. His pedi said it could take a few weeks for maximum effect, but it helped right away. He couldn't lay flat at all - he slept in the rock n play. Soon after starting Zantac he was able to sleep flat. He still spits up a bit, but he's not screaming bloody murder now.
We also give him a bottle thickened with oatmeal cereal at night, per ped/Children's Hospital recommendation.
Liam has been on 2mL of zantac for reflux since May. I can't even tell you what a difference it has made in our home!! before starting it, he would take about an ounce of formula and start screaming like he was in pain and refuse to eat any more. the only time he would eat peacefully was when he was practically asleep. i was convinced he had colic, and within a week i could have sworn i had a different baby. he rarely spits up now and is a happy, chunky little man!
we are going to talk to his pedi at the 4m appointment about when to wean him off of it. i'm thinking when he's eating solids consistently we will see what happens with a lower dose.
I hope you have as much luck as we did! FWIW, i was never able to get Liam to just take the medicine from the syringe. i mix it with 2oz of formula first thing every morning so i know that he gets every drop. every time i mixed it with a full bottle, he never would finish the whole thing. GL!!