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I've been on the mini pill, combo pill, depo shot, and now have Mirena.
Pros of Depo Shot: easy, just one shot every 3 months. You have to go to an office to get it done, so depending how you feel about doctor's appointments vs waiting at the pharmacy this may be a pro or con.
No cycle, which I thought was awesome.
Cons of Depo Shot: I did gain some weight (15-20lbs), though I don't know if that was due to other factors going on at the time (long work hours, no exercise, bad diet). When I went off the depo shot, I was able to lose all the weight, but again, there were other factors at the time (shorter work hours, biking to work, and better diet habits).
It took 9 months after my last shot for my cycle to return and a full 15 months after my last shot for it to approach something predictable so that we could start TTC.
Mostly, I liked it. It was easy and I didn't have to think about it. Side effects weren't great, but I could live with them.
ETA: I was on it for 2 years. No weight gain the first year, it was the second year it all showed up.
oliversmom03:I have not personally used it, but a lot of my girlfriend's have. Every single one of them has gained weight on it, so I stay clear of it. I mean, like 20 pounds. Good Luck to you in whatever you decide.
Just thought I would respond to this and say that I have not gained any weight since being on it. But that is a listed side effect. Also, I was told to make sure I take calcium daily because it somehow uses up the calcium in your system. I can't explain that at all, but I do make sure to take my calcium.
I think if you really struggle to remember to take the pill, if you have painful or heavy periods normally and if you are ok with a long-ish term BC, it can be a good choice. I definitely warn you about the weight gain, it is a frequently seen side effect. Also the bone density issue is an important one to consider, though I believe it is seen much more in women who use depo for over 2 years. There is a black box warning on that. Last issue is that it is not always quickly reversible and can take women much longer to get pregnant after going off it (hard to predict who will take longer & how long) so if you are considering pregnancy anytime in the next year or two, you may want to consider that possibility as well.
Have you considered nuvaring or implanon?