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Give gas drops when he gets fussy and draws his legs up toward his chest. Those are usually indictors of gas.
I've tried the simethicone drops and I'm not sure if they work. I usually give grip water now instead. DD seems to like those!
We use "Little Remedies" brand gas drops (simethicone drops). (We would have used any store brand though if it was available) We can tell she's gassy because she "toots" a lot, and also grunts and draws her legs up to her tummy.
ETA: They seem to work for her