Trouble TTC

Clomid effect on lining?

This is my 4th clomid cycle, all 4 on 50mg, and the first time that it's thinned my lining. If I stop clomid after this cycle and switch to something else in the future if this IUI doesn't work, will my lining eventually recover to where it should be? In other words, I guess I'm wondering whether the damage is reversible? I'll ask my RE when I see her next, hopefully tomorrow, but this morning I just saw an ultrasound tech briefly.

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TTC since Sept 2011, Unexplained IF
Oct 12 - Jan 14: 3 clomid/TI cycles, 2 hysteroscopies, 2 IUIs, 1 BFP (MMC @ 12w), 2 more IUIs
Feb 14: Gonal-f + IUI #5 = BFP! (EDD 11/4/14)
Baby boy arrived 11/13/14!

Re: Clomid effect on lining?

  • Have you had breaks in between cycles? My RE won't do more than three medicated cycle without a "break" cycle in between to allow your body to reset. Clomid/Femara/Letrozole inhibit estrogen receptors, so yes, your lining might decrease. But it can be just fine the next cycle. It's not cumulative. I had lower linings on clomid/letrozole- mine were always around 7. Now that I'm on injectable drugs, with no clomid/letrozole, my lining is fine. They can also give you estrogen patches to help bump up your lining.
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  • katib77katib77
    10000 Comments Sixth Anniversary 250 Answers 500 Love Its
    Yes, it is reversible. I had poor lining that got worse with each of my three clomid cycles to wherr my RE said "never again"...and we moved on to injects. Now my lining is better than it ever was on clomid.

    TTC since July 2009. Dx MFI & LPD. 
    IUI#1&2&3 (2011 & 2012) BFN
    IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
    IUI#5 BFN (April 2013)
    IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
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    Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
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  • rox825rox825
    2500 Comments 250 Answers 500 Love Its Second Anniversary
    I have had a break in between, I did 2 in the fall and just started treatment again last cycle. I'll probably take a meds break after this one if it doesn't work to rest things, and maybe try injects next. Thanks ladies, I can sleep a little easier tonight!

    Baby Birthday Ticker Ticker

    TTC since Sept 2011, Unexplained IF
    Oct 12 - Jan 14: 3 clomid/TI cycles, 2 hysteroscopies, 2 IUIs, 1 BFP (MMC @ 12w), 2 more IUIs
    Feb 14: Gonal-f + IUI #5 = BFP! (EDD 11/4/14)
    Baby boy arrived 11/13/14!

  • Definitely reversible, but it can be cumulative if you're really sensitive to it (like apparently I am!). Clomid takes 6 weeks to clear your system, which is why you may not see much of an effect the first round, but more of an effect the second (or third, or fourth) round. My lining got progressively worse, but after two break cycles, it's recovered to be perfect (in the words of my nurse!). But my doc has sworn me off Clomid forever now.

    Just make sure you don't do another Clomid cycle next month (though hopefully this is your cycle and there isn't a "next month" for you!). Good luck! 


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  • HalsingHalsing
    500 Comments 250 Love Its First Anniversary Name Dropper

    Thanks for asking this - I had been wondering the same thing!

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