Infertility

And our IVF journey begins...

Quick reminder: I am the carrier of an x-linked genetic disorder, so we will be doing IVF with PGD to avoid passing it to our children. I also have endometriosis and my husband has low morphology (under 4). To put it bluntly, I am terrified and so darn excited to get this ball rolling. We had our initial consult back in December. 

The PGD probe (developed to test for my family's disorder) will be developed over the course of the next 14 weeks. We will do our cycle before the test is done and freeze any embies we get. We have to use ICSI because with PGD it is critical for only one sperm's DNA to touch a given egg. I found this interesting and wanted to share. On day 5 after our ER, the biopsy (single cell) from each embryo will be taken and cry-preserved until our probe is complete in late May. Once the probe is complete, we will test the embies. We are likely to have a 23% "healthy" embryo rate after PGD testing (statistically eliminates 50%) and PGS testing to check for aneuploidy (statistically eliminates more...can't remember the number) and supposedly after all the eliminating, we are likely to have a 23% healthy embryo rate. 

Tomorrow we meet with our RE for a check-in and to lay out our "plan." I'm hoping I'll be a late March lucky duck and an early-April "?" for ER. :) It feels like it has been a several year journey to get to this appointment...after finding out I'm a carrier, and then doing all the darn fertility tests...I am so ready for our plan.

Any advice on what to be sure to ask the RE since we will have her to ourselves for an hour tomorrow? What did you ask at your "create a plan" appointment?  

| Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
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PAIF/SAIF/Everyone Welcome! 


Re: And our IVF journey begins...

  • No advice but lots of luck! We are on cycle #2 for IUI so I feel ya for the anticipation and nervousness *hugs*
    Me: 31 DH: 33 Married : 12 Years going on 16 years together TTC since 9/2001 11/2012 100 MG Clomid 12/2012 200 MG Clomid: IUI 12/26 2 Week Wait Praying for a miracle
  • I would probably ask stuff related to the protocol and timing. I must say I didn't ask that many questions on my first time around. I just wanted to go with the flow and trust the RE. Good luck with your appointment! 
    Me 32 / DH 36
    TTC since 08/2010
    Me: Lap in 2007 due to pelvic pain: Dx mild endo
    Lap in 2011: ovarian cyst and endo removal
    2 Clomid cycles: good response but both BFN
    borderline high anti-cardiolipin IgM Abs - now on baby aspirin
    DH: S/A low all three - unexplained

    IVF/ICSI #1: 06/2012 11R/11M/9F 2dt of one 4-cell embie - BFP,
    beta hell, U/S hell, m/c and D&C in 08/2012
    FET #1: 10/2012 3dt of one 10-cell embie - BFN
    FET #2: 11/2012 2dt of one 2-cell embie - BFN
    FET #3: 01/2013 3dt of one 6-cell embie - BFN
    IVF/ICSI #2: 02/2013 14R/13M/7F 5dt of one blast 2/16 - BFP, beta hell, ectopic

    image image
  • Best of luck to you and your husband on this journey!
    Me 34/DH 44 Me: Low AMH (.21) DOR, mild endo; Started seeing RE 11/12
    Jan-March '13 3 IUIs Clomid + Trigger = BFN
    April '13 IVF 1 MDLF converted to 4th IUI due to 3 runaway follicles! BFN
    July/Aug '13 IVF 1.2 Long Lupron = 7R, 6F, 2T= BFP!!!
    Beta 1=512, Beta 2=1,368 Beta 3= 4,128
    It's a boy!!!!
    SUA, GD
    EDD 4/26/14
    PAIF/SAIF Everyone Welcome

    He's Here! Arrived 4/15/14!!!!
  • Wow it is really mindblowing-the stuff they can do these days!  I wish you luck in your journey!

    image
    IVF #1 Jan 1, 2013-Bravelle (150) and Menopur (75)
    Jan 15 Trigger shot, Jan 17 ER, Jan 22 5 day transfer (2 embryos) Feb 1st-3rd + HPT Feb 8th-Beta 1: 2013! Feb 11th-Beta 2: 3100 Feb 15th Beta 3: >5000! Faint heartbeat seen at 5 weeks 4 days! 3/7/13 U/S missed m/c at 8 weeks.

    image
    FET June 20, 2013 Beta #1@13dpt July 3: 2,476!! 1st U/S 7/9/13 revealed 2 sacs w/ yolks @ 5w3d! U/S #2 July 16 shows 2 heartbeats baby a 111 baby b 117! July 23 U/S-baby a 163 baby b 134 July 25 U/S baby b does not have a heart beat anymore :( 
    Due March 7th, 2014 TEAM BLUE!
    Baby boy was born 3/5/2014!
  • Best of luck to you!! Science is an amazing thing!
    Me - 35 DH - 37 SD - 10
    Married 10/8/2011
    Started TTC July 2011. Infertility workup July & August 2012.

    DH - all clear. Me - Unicornuate Uterus discovered at HSG 8/16/12. Referred for IVF 8/28/12. Approved for IVF Warranty Program 10/2/12. Laparoscopy 11/1/12 - removed right rudamentary horn, both tubes, left ovarian cyst and endometriosis.
    Given all clear for pregnancy after 1/1/2013.


    IVF cycle 1 starts 1/19/13!

    12 eggs, 7 mature and all 7 fertilized - 2 Frosties!!

    5 day SET 2/4/13 - Beta 2/13: 86 & 2/15: 186 BFP!!!!

    EDD: October, 23, 2013



    Blog: http://journeyofaplayer.wordpress.com/





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  • Hey Rosy, I was just wondering if the x-linked disorder you are testing for is Fragile X?  I am at intermediate risk for it but found out after the cycle began.  They told me that they couldn't test the embryos since the probe was not yet made.  Sounds like you are making that happen :)  Good luck!

    <Image and video hosting by TinyPic
    Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
    April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
    cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
    cycle 2: June 2012, femara 5mg; cycle cancelled, no response
    cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
    Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
    Aug. 8: met with RE, move to injectables if HSG and SA normal
    Aug. 23: HSG all clear; DH- perfect
    Switched to a new RE in early Sept. IVF here we come
    Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
    IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
    IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147 :(, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.

    FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks.  8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.

    12/1: met with RE to discuss trying for #2


  • Hey BrideJackie, no, it's not FragileX. The testing is for a super rare xlinked disorder. : if you decide you want to know more about creating a probe in the future, feel free to contact me through a PM!
    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


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