Infertility

Which Progesterone?

Progesterone in Ethyl Oleate (Injectible progesterone?typically cheapest option but it is an intramuscular injection)


OR

Endometrin 100mg tablets (tablet inserted vaginally; three times a day?)


OR

Crinone 8% (gel inserted vaginally; once a day?)

 

Ready, Set, Debate....  Wink

Married 2005 | DH & I are 33 | DH diagnosed with CAVD & I have PCOS

IVF #1: February 2013
ER 02/13 15R, 12M, 10F
ET 02/18 5DT of 2 beautiful AA Blasts! (none to freeze)
Beta Hell resulted in Chemical Pregnancy
RE shares our concerns about egg quality.
Taking a mental & physical break (with vitamins & weight loss!)

IVF #2: July 2013
ER 07/03 12R, 8M, 6F
ET 07/08 5DT of 1 Early Blast & 1BB Blast
(none to freeze, again)
HPT & Beta 07/17 - BFN

IVF #3: April 2014
New RE (yay!)
ER 04/07 37R, 35M, 26F
Froze 5 Beautiful Blasts
PGS shows 3 are "Normal"
Prepping for FET in May!


Daisypath Anniversary tickers

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Re: Which Progesterone?

  • I'll be on crinone at some point very soon. I've never done it before

    Unmedicated and medicated IUI's: all fail
    IVF #1: Dec 2012 16m/15f 12/9: 5dt of 2 beautiful blasts and 5 frosties
    TWINS!
    15w4d:baby a-pProm
    March 25: 18w...2 baby boys born sleeping
    July 29: FET-BFN

    Sept: TAC placed

    Oct 27: FET #2-Cancelled-monster cyst producing insane amounts of estrogen

    Nov 13: FET #2-take 2
    imageimage

  • Are you asking which is more effective or which is easier?

     

    Of these I've only done Crinone and didn't have any issues with it. The "gunk" wasn't even that much or bad for me. If I do IVF again my RE wants me to try PIO, but I'm not sure how that would play out as DH is not an injection giving kind of guy so I'd have to give them to myself. Boo!


    ***signature & ticker warning***


    Me: 30 ~ Stage IV Endo ~ AMH .38 ~ AFC 8
    AMH .97 as of 4/2012! ~ AMH 1.63 as of 4/2013!?!

    Him: 28 ~ perfect swimmers
    Laparotomy w/partial oophorectomy 8/2009 to remove cysts/endo.
    Stopped BCP 4/2010.
    Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN
    IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN
    IVF:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embryos txfrd. ~ BFN
    BCP to manage endo from 10/2012 to 12/2012.
    FET w/donor embryos #1: 10/2013 Cancelled
    FET w/donor embryos #1.2: 11/2013 ~ ET of 2 beautiful blasts on 11/27.
    Beta 1: 503(12dp5dt) Beta 2: 1035(14dpt) Beta 3: 3001(16dpt)
    Beta 4: 8503(19dpt)
    Twins with an EDD of 8/15/14! Team Purple

    If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus!


    image
  • I did PIO my first cycle it wasn't that bad for me. I'm doing the endometrin suppositories and they suck! They are a leaky gooey mess! I don't have experience with Crinone so I can't comment.

    Me 38 MH 40 - TTC since June 2010 - dx with Severe MFI. Straight to IVF with ICSI. IVF #1 - ER 06/13/12 - 9 Eggs Retrieved - 4 ICSI'd - only 2 fert. 06/15/12 - 2DT - 3 cell & 6 cell with fragmentation. Beta 06/29/12 - IVF #1 = BFN. 07/20/12 - WTF Appt -Told by our RE to quit IVF. Second Opinion from RE is good. IVF#2 - November 2012. Estradiol Pills Started 11/6. Stims start 11/16. ER 11/26 - 7 eggs retrieved - all mature. 4 fertilized with ICSI. ET 11/29 Transferred 3 embryos. Beta is 12/10. 1st Beta 81 2nd Beta 160 and 3rd beta 360!!! First U/S 12/21/12 - We saw one beautiful gest. sac. 2nd U/S is 01/04/2013 - H/B 183 02/05/13 - NT Scan - everything looks good and IT'S A BOY!  Aiden born 08/20/2013.  TTCing on our own and contemplating when to begin IVF treatments again for baby #2.


     "Everything will be okay in the end. If it's not okay, it's not the end."


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  • I am doing PIO.  They aren't so bad, at least from what I thought they were going to be.  I've had to give the last few myself as my DH went out of town.  It actually hurt less (as in not at all) when I do them.  So now he isn't allowed, I choose to do it myself!!
    Too Positive to be doubtful, Too Optimistic to be fearful, and Too Determined to be defeated.
    image
  • I'm on the PIO as well and as much as I was scared of allowing DH inject me, I'd choose it again....even with my new POI lovely lady lumps.  Probably because I KNOW my body is absorbing it.

    Me- 32, DH- 32- TTC for 4 Years
    IUIs 1-6 BFN
    IVF #1= BFP- M/C
    FET- Beta#1: 69, #2: 482, #3: 1088, #4: 28,318, Ultrasound- 1 beautiful heartbeat
    It's a boy!

     BabyFruit Ticker

  • I was prescribed Crinone.  When I went to fill it the pharm tech told me it would be $18.  I thought hey-pretty good!  She later came out to inform me that she made a mistake it is $18 each, not total.  So for the 30 my doc prescrible it would be over $500.  We are OOP for meds-so I am going to ask her about the IM injection-she did tell me it would be cheaper, and to let her know if the crinone was too expensive!  Just trying not to think about it being IM.  I don't have a problem with the sub-q but not sure if I could do that.  My hubby already informed me that he won't to it to me.  My sis is a nurse-I think I'll be hitting her up for help! 
    TTC naturally since Nov 2010.
    Diagnosed with PCOS in June of 2012
    Started seeing a RE June 2012
    HSG showed a block left tube
    Hubby's SA showed a slightly low count everything else ok
    Three rounds of Clomid/IUI-all three rounds IUI were cancelled because follicles never matured.
    Starting injections for IVF Dec. 1st. Praying for the Christmas gift of a lifetime!!!

    11/30 Baseline U/S and bloodwork-everything looks great!
    12/1 Start Stims
    12/11 ER
    16R 7M 7F

    12/16 ET

    12/26 Beta #1 364
    12/28 Beta #2 758
    12/31 Beta #3 2249

    12/31 Ultrasound showed...TWINS!!!!!!

    2/4 Ultrasound showed one baby with HR of 174 and one angel baby.

    image


    BabyFruit Ticker


  • My RE had me alternate days between Crinone and PIO. Crinone is super easy, and PIO really isn't too bad yes, its IM. Next round, we are doing only PIO though because my progesterone blood work came back low, and as Crinone isn't necessarily picked up on b/w, we decided it would be easier to monitor if I was just using PIO.
    image. image
    Me: 35, DH: 36, ttc: 5 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid med & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. CFNBC.
  • Loving the feedback!  I wasn't asking about anything specific, but am definitely curious about the "experience" with each.  This may sound strange, but I'm such a prude the thought of the gel or tablets totally freaks me out.... I don't even use tampons!!!  Haha!!  However, I'm not a needle fan either... if I see them I faint!  I have issues.  LOL
    Married 2005 | DH & I are 33 | DH diagnosed with CAVD & I have PCOS

    IVF #1: February 2013
    ER 02/13 15R, 12M, 10F
    ET 02/18 5DT of 2 beautiful AA Blasts! (none to freeze)
    Beta Hell resulted in Chemical Pregnancy
    RE shares our concerns about egg quality.
    Taking a mental & physical break (with vitamins & weight loss!)

    IVF #2: July 2013
    ER 07/03 12R, 8M, 6F
    ET 07/08 5DT of 1 Early Blast & 1BB Blast
    (none to freeze, again)
    HPT & Beta 07/17 - BFN

    IVF #3: April 2014
    New RE (yay!)
    ER 04/07 37R, 35M, 26F
    Froze 5 Beautiful Blasts
    PGS shows 3 are "Normal"
    Prepping for FET in May!


    Daisypath Anniversary tickers

    imageimage
    image
  • I've only used Endometrin and Crinone... my RE doesn't use PIO. 

    The dirty details, neither of them are really that pleasant.  I find the Endometrin to be less messy.  Meaning that there are occasional chunks goop that come out, but it isn't too bad.  My nurse also recommended a "finger sweep" to help with some of the larger pieces that aren't absorbed. 

    A pantyliner is a must with both.  The Crinone on the other hand... EWH!  Much messier! 

     Hope this info helps! :)

    ttc since fall 2009 me: 32, PCOS, high FSH, DOR, HSG normal DH: 35, perfect 4/7/12 Clomid - Trigger - IUI#1- 2 HCG boosters = BFN 5/11/12 Clomid - Trigger - IUI#2 - 2 HCG boosters= BFN switched RE's 7/2012 8/27/12 Gonal-F, prog - IUI #3 = BFN IVF #1 November 2012 - BFN All are welcome! image
  • I've never used Crinone, but of the other two, I definitely prefer the Endometrin. I hated those PIO shots so much. They don't hurt going in but afterward was nonstop (though admittedly not serious) pain, lumps and soreness. I still have lumps in my butt from those shots, months after my cycle ended. No gross discharge can be as bad as that, in my humble opinion.

  • I was on progesterone until 13 weeks pregnant. I've done all three.

    PIO is cost effective, but hurt like a muthah!!!

    Crinone required vaginal sweeping, which is gross and weird, but not that big of a deal. Best done in the shower...

    Endometrin has to be administered more often and for me, resulted in a slow and steady stream of nastiness.

    Good luck picking!
  • I use the injections.  The pills that you can take orally or vaginally made me crazy.  I always get the fun reactions.  Poor dh was so scared of me and I was scared for him.  So the cream one was my next choice but it was hundreds of dollars and it is all oop so I do the injections.  Dh gives them to me and if he is out of town my dad does it.  More poor dad had to give me the trigger once too.  He is so good to me.
    Married 12-12-04
    TTC since 07
    me-36 PCOS, Tubal Problems, and polyps removed 7-12
    DH - 36 extremely handsome and no fertility problems
    IUI 8-12 and 9-12 failed
    IVF 12-21-2012 - 2 I think perfect no matter what the dr graded them (2B)embryos transferred Beta on 12-31-12 Positve - Beta is 21
    Beta 2 1-2-13 - 31
    Beta 3 1-4-13 - 53
    Beta 4 1/9 - 212!
    Ultrasound 1/10 - Nothing completely empty uterus Beta 1/14 - 743; Beta 1/17 - 1704 ultrasound shows nothing. Officially a miscarriage. 1/21 Beta 3900 Dr. says it ectopic. Ultrasound shows a miracle heartbeat right in the uterus where it belongs! Dr. says I can be cautiously optomistic!!! Hang in there baby!
    [IMG]http://i50.tinypic.com/2pye4xi.jpg[/IMG
    ]
  • I used PIO with some numbing cream. I had a sore behind here and there but nothing major. DH always did the shots. After hearing about the other two, PIO sounds easy!
  • Yeah, I'm leaning towards the shots.... which I NEVER would have thought I'd say that in my life, but the other stuff freaks me out and I need to save money anywhere I can!
    Married 2005 | DH & I are 33 | DH diagnosed with CAVD & I have PCOS

    IVF #1: February 2013
    ER 02/13 15R, 12M, 10F
    ET 02/18 5DT of 2 beautiful AA Blasts! (none to freeze)
    Beta Hell resulted in Chemical Pregnancy
    RE shares our concerns about egg quality.
    Taking a mental & physical break (with vitamins & weight loss!)

    IVF #2: July 2013
    ER 07/03 12R, 8M, 6F
    ET 07/08 5DT of 1 Early Blast & 1BB Blast
    (none to freeze, again)
    HPT & Beta 07/17 - BFN

    IVF #3: April 2014
    New RE (yay!)
    ER 04/07 37R, 35M, 26F
    Froze 5 Beautiful Blasts
    PGS shows 3 are "Normal"
    Prepping for FET in May!


    Daisypath Anniversary tickers

    imageimage
    image
  • I tried injection, both olive oil and ethyl oleate, and I tried the endometrin.  I thought the shots were less messy.  I am not a pad wearing person... so it was annoying to be dealing with that all the time.  I was on the progesterone shots for 8 weeks straight, and it was better for me that way.  Ethyl oleate is better than olive oil by far!
    BabyFruit Ticker 9 Failed IUI 1 very lucky IVF, 14 eggs, 5 low quality embryos all transferred -BFP Thanking my lucky stars to have this little one growing.
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