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I was on it for years. I do better with progesterine (sp?) birth control vs. all the estrogen ones. I loved it. When I first was placed on it, I was warned that it will make me feel hungrier, so I shifted to higher protein, lower carb meals to bring my appetite down, and then I actually lost weight on it. From there, I didn't have periods, which was great. I didn't have spotting or anything. I eventually was asked to go off it because it's not good for bone density issues to be on it long term ( I had used it for ~10 years). I liked that I only had to think about it once a quarter. When I went off it, and switched, I never found a b.c. that I liked as much or tolerated as well. Depo to me was symptomatic free.
I was on it for 5 years before getting pregnant with DD. 5 years is the max they want you to be on it. If you're on it longer there's a chance it'll mess with your reproductive system. I LOVED being on it. I had gotten my last shot January of last year, which meant it was out of my system in April. I got my period back in June & got pregnant in September. While on it I didn't have a period after the first couple months or so. Rarely I would have spotting.
The only time I gained weight was when I went from vegan to vegetarian (started eating dairy again). Other than that, the only side effects I had was nausea &, during the first couple years, the occasional chest pain.
I'm on it again now. Got my shot Friday at my 6 week appointment. Happy to be on it again!!