Are you using colace too? I feeL like I'm in this battle because I only take the zofran on days that I'm vomiting but then I have the worse constipation from it. That pain is no fun at all either. My doctor said it's fine to take colace but it's class c so it makes me nervous. I've done the fiber, water, fruit etc but nothing helps. I started off this pregnancy on penicillin, then amoxicillin, another antibiotic shot, zofran, and now colace. I feel like the bean is getting a little loopy in there.