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I think they are both excellent hospitals. The two main hospitals (CMC and Presbyterian downtown) have the highest level NICU's, where the 'suburb' hospitals (CMC University, Presby Huntersville, etc) have lower grade NICU's. It was important to me when we were looking, and my son unexpectedly ended up in the NICU for a week after birth, so i'm glad we were in a hospital with the highest level care. I gave birth at Presby main and had a C-section,so this didn't matter to me, but I think at both main hospitals you labor/delivery in a certain room, then move to a post partum room for the rest of your stay. I think some of the suburb hospitals have "all in one" rooms where you birth/recover in the same room and they tend to be a bit bigger.
FWIW, my mom is a nurse and she tells me "if you're ever in an accident make them take you to CMC uptown"...she thinks its the best based on her experiences.
I 2nd CMC! Just do a search on this board and you'll find great reviews. For the Mommy who wants a natural birth, Midwives and great breastfeeding support go to CMC. Feel free to read my birth story. I delivered at CMC Pineville :o)