I just found out that I have the homozygous A1298c MTHFR mutation. I have had 2 pregnancy losses. The first was a possible, but never confirmed, ectopic. Second was a 4 1/2 week natural miscarriage or chemical pregnancy. (sac never seen) I also a few family members with Factor IV leiden or some varient, so my OB wanted me to get tested for that and other disorders since I had back to back losses. I am negative for Factor IV, thankfully. But, I do have the MTHFR mutation. My OB suggests I see a Genetic Counselor about this. Does anyone else here have this mutation? Are you on any meds? Did you see a Genetic counselor? I have been searching google (bad me!) and not found any good answers. Thanks for your time!