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If they are growing very fast (as a spurt seems to imply) they certainly can have growing pains. Around 6th grade I had daily migraines. After lots of fun talks with the doctors and chiropractors one of them finally xray'd me. My spine didn't keep up with my latest growth spurt and 'stretched' a little. This caused the little tab-looking bone at the base of the skull/top of spine to press into my skull when my spine caught up to my growth. Wow was that fun! I had gone from aching back to daily blinding migraines.
I can't blame a baby whatsoever if they are fussing during a growth spurt! I also agree that because these changes will disrupt the self-imposed schedule that they will be fussier in general just due to tired/irritability. Alyssa's spurts so far have seemed to fall more under this and not so much the pains thankfully. You could almost compare this to daylight savings when we switch up our schedules, those first couple days aren't very easy for many people.