Pregnant after IF
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Progesterone in oil

I am in so much pain from these shots! The actual injection isn't so bad- it's several hours later. I can barely walk and my leg just throbs. I am on high doses and do the injection daily but this seems really bad! I do the heating pad, massage, etc and still so bad. I tried in ethyl oleate but it didn't make a difference. Anyone else experience anything like this?

Re: Progesterone in oil

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    I'm pretty sure everyone who does PIO injections feels pain afterwards. I've never had my legs throb, but it has been difficult at times to walk. I'd ask your doc and see what s/he says. They may be able to switch you to suppositories instead if it truly that bad.
    About us:
    Me - 28, Lean PCOS
    DH - 31
    Married June 2010, TTC since March 2014
    Blog: ourbinarystar.com

    FET cycle #3 Transfer July 28th 2016, Triplets born healthy on February 26th 2017 at 33w1d!

  • Options
    I was having the same problem if I went in too close to a previous injection spot.... I went back to the RE and had them show me how big of an area I could work with  (was a lot bigger than they originally told me).... that really helped me..... but at times it was unavoidable since they seemed to 'heal'  at different rates. I didn't worry about switching sides, just tried to find the spot that felt the best. Good luck - they suck

    --------

    Me: 42 | DH: 39 | Us: Married since April 2014 | TCC 20 months before IVF

    Me: unexplained infertility (AMA?) | DH: No issues

    1st IVF cycle with ICSI & PGS | ER 1/21/16  | FET  4/26/16, ectopic

    2nd FET 09/20/16 | DS born May 2017

    3rd FET 09/14/20

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    Is it possible you hit the sciatic nerve with them? That's what happened to me. My right side was throbbing, tingling and then kind of felt like it lost sensation. I was switched to suppositories after that. This almost went away eventually. I say almost because to this day my right side of my butt and thigh still feel a little weird to the tough, as if not all sensation is back over there. Definitely speak to your doctor and see what they'd suggest. 
    ***History & TW in Spoiler***

    ***bfp & child warning***
    TTC - since 2014
    7 rounds of Clomid - BFN
    IUI #1 - October 2015 - BFN
    IUI #2 - November 2015 - BFN
    IUI #3 - December 2015 - BFN
    IVF #1 - March 2016
    Retrieval #1 - April 2016
    FET #1 - May 2016 - BFP!!! DS - Born January 2017
    Trying for baby #2...
    FET #2 - January 2018 - BFN  
    No more embryos left; switched to a new RE
    IVF/Retrieval #2 - January 2019
    IVF/Retrieval #3 - March 2019
    FET #3 - April 2019 - BFP!!! - DD: Born December 2019
    Trying for baby #3...
    FET #4 - October 2021 - BFP!!! - Due June 2022


  • Options
    I was having a lot of pain my first week on PIO. But then I discovered that we were actually doing the shots too low and moved them up closer to the love handle region (think above the top of your butt crack) and then my pain decreased significantly.

    Here's a great video to watch to learn the proper spot for the injection: https://www.youtube.com/watch?v=A-EY_4P67Hs
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
  • Options
    Thanks all! I appreciate all the responses and will try these tips!
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    I was having pain last cycle, but I noticed that my husband was pressing too hard. I also switched to doing them in the morning. I used to do them at night, but I find doing it in the am is much better. Walking all day helps work the oil into the muscle, where as at night- im usually sitting afterwards and then going to bed. 
    Me 30 || DH 36
    Unexplained Infertility- Postive for MTHFR Gene Mutation

    Natural cycles with 1 miscarriage
    -3 IUI's w/ Clomid= BFN 
    -IVF #1-Follistim and Menopur= BFN
    ***11 Eggs, 10 mature, 8 fertilized, transferred 1 (day 5) 2 made it to freeze
    -FET #1- Transferred 2, day 5 embryos =BFN
    -IVF #2- Follistim and Menopur = BFN
    ***11 retrieved, 8 mature, 6 fertilized, transferred 2 (day 3), 4 made it to freeze (Follistim and Menopur) = BFN
    -FET #2- Transferred 2, day 3 embryos = BFN
    **Changed doctor**
    -IUI #4- natural cycle = BFN
    -IUI #5- Follistim (5 eggs) BFP- lead to Miscarriage  :'(
    -Laproscopic Surgery for Endometriosis, Polyp removal and Cyst removal. 
    -IVF #3- Menopur, Follistim, Lupron, Ganirellex- BFP lead to Eptopic Pregnancy  :'(
    ***11 Eggs retrieved, 10 Mature, 8 fertilized, transferred 3 embryos (day 3), 0 made it to freeze
    -Lapropscopic surgery- Removal of Fallopian Tube
    -IVF #4- Estrogen Priming with Vivelle dot, Menopur, Follistim, Ganirellex- BFP  :)
    ***15 Eggs retreived, 11 mature, 11 fertilized, 2 embryos transferred (day 3), 2 made it to freeze
    Found out I was positive for MTHFR Gene Mutation during TWW of IVF #4

  • Options
    @colleen0516 - does your RE not have a PM only rule? I asked to switch mine to the AM and was told no - something to do with absorption rates.
    *** TW**

    Me: 37, DH:39
    Met: 2002 | Married: 2004 | TTC since January 2014
    July 2015: MMC @ 9 wks | August 2015: Chemical
    March, April, May & June 2016: Medicated IUIs | BFN 
    August 2016: Started Stims 8/22
    September 2016: Egg Retrieval 9/4 | 13 Mature Eggs | 10 Fertilized | 3 Blastocytes | 1 PGS Normal Embaby 
    November 7, 2016: FET - BFP!
    EDD 7/25/17
    Zoey Alexis born 7/25/17 @ 12:39 PM | 7lbs 14oz | 19 inches
  • Options
    @byrneme my doctor told me either AM or PM is fine but to be consistent. She said it should be at the same time each day, with a 2 hour buffer.
    Me 30 || DH 36
    Unexplained Infertility- Postive for MTHFR Gene Mutation

    Natural cycles with 1 miscarriage
    -3 IUI's w/ Clomid= BFN 
    -IVF #1-Follistim and Menopur= BFN
    ***11 Eggs, 10 mature, 8 fertilized, transferred 1 (day 5) 2 made it to freeze
    -FET #1- Transferred 2, day 5 embryos =BFN
    -IVF #2- Follistim and Menopur = BFN
    ***11 retrieved, 8 mature, 6 fertilized, transferred 2 (day 3), 4 made it to freeze (Follistim and Menopur) = BFN
    -FET #2- Transferred 2, day 3 embryos = BFN
    **Changed doctor**
    -IUI #4- natural cycle = BFN
    -IUI #5- Follistim (5 eggs) BFP- lead to Miscarriage  :'(
    -Laproscopic Surgery for Endometriosis, Polyp removal and Cyst removal. 
    -IVF #3- Menopur, Follistim, Lupron, Ganirellex- BFP lead to Eptopic Pregnancy  :'(
    ***11 Eggs retrieved, 10 Mature, 8 fertilized, transferred 3 embryos (day 3), 0 made it to freeze
    -Lapropscopic surgery- Removal of Fallopian Tube
    -IVF #4- Estrogen Priming with Vivelle dot, Menopur, Follistim, Ganirellex- BFP  :)
    ***15 Eggs retreived, 11 mature, 11 fertilized, 2 embryos transferred (day 3), 2 made it to freeze
    Found out I was positive for MTHFR Gene Mutation during TWW of IVF #4

  • Options
    My injection areas are still off and I haven't had a shot for 11 weeks. I asked my ob a few weeks ago if this was normal and they said you do a number on the injection areas and it will take a while to heal. Towards the end my welts weren't going away, I think your body has a hard time healing that area and after a while it starts to take longer for the oil to obsorb. Wish we all had better responses but they were super painful for me as well
  • Options
    I always do morning. Yeah, I think the oil just builds up so it gets more and more painful. After a while there just isn't any "safe" space left!
  • Options
    I hate to say it, but I'm at 33+5 wks pregnant, so it's been about 19 weeks since my last shot, each injection area is still somewhat numbbto the touch, though it's slowly gotten better.
    Married May 2009, TTC since November 2012 (Together since 2006 ish - had my eyes on him since 2001)
    Me: 32 (33 in May), Him: 37 (January)

    DX: Me: High Prolactin, Possible Autoimmune Disease Issues, though RE not concerned (?)  New RE has a plan!!
           Him: Minor Varicocele, low morphology, slightly low count

    History:

    Beta 5/9/2016 BFP!!
    Embryo transfer scheduled for April 28, 2016 and beta test May 9, 2016 (day after Mother's Day!)
    Transfer Meds include: Lupron Depot (4/1), Minivelle Patch (every 3rd day), Estradiol (3x daily), Amoxicillin, Progesterone in Oil, Methylprednisonlone. Lovenox and baby asprin added after transfer. 

    3/22/16 - Sono Saline ultrasound cyst to be aspirated on 4/1/16 if not cleared up by 3/29 US - It cleared on its own
    Retrieval 3/4/16 - 26 eggs retrieved, 23 mature, 20 fertilized, 14 embryos currently frozen
    Starting IVF Stims on +/- Feb 22, 2016
    HSG scheduled for 1-26-16 - All clear "beautiful uterus" (though inverted)

    Switched clinics and now prepping for IVF in February / March

    Fourth IUI -  CD3-7 100 Clomid w/ Ovidrel Trigger - December, 2015 - BFN
    Third IUI -  CD3-7 100 Clomid w/ Ovidrel Trigger - November, 2015 - BFN
    Second IUI - CD3-7 100 Clomid w/ Ovidrel Trigger - September, 2015 - BFN
    Started Prolactin Medication October 15 - Levels quickly regulated to with in normal range
    First IUI - CD3-7 100 Clomid w/ Ovidrel Trigger - August, 2015 - BFN
    After no BFPs (ever) First RE/Urologist visit in Feb 2015
    HSG w/ OB, 2014 = all clear
    Trying to conceive since November 2012
  • Options
    Ugh, sorry you girls are still having pain!

    Just wanted to offer a different perspective for anyone who might be reading and freaking out: I had zero pain with my shots. Well... I think once my hubby hit a vein or something and my leg went a little numb and I bled a lot. That wasn't fun... but everything was normal after that! After my last shot @ 10 weeks, my booty healed and I feel like I did before the shots. It all just depends on the person I suppose.... but I think everyone here will agree that it is SO worth it!!
    *TW - Pregnancy mentioned*
    Me: 28 DH: 33, Married May 2014
    3 failed IUIs Dec '15 - Feb '16
    IVF April/May 2016 - 1 failed fresh transfer. 11 snow angels.
    1st FET 7/29/16 = BFP
    Lawson arrived on 4/24/2017 at 7lbs 15oz, 21 1/2 inches long!
    Surprise pregnancy!! Baby #2 due 10/11/18 <3
  • Options
    I had excruciating pain with my shots.  I could barely walk.  I ended up switching to my thigh and made sure my leg was fully bent to stretch the muscle before the injection.  This helped a lot.  If you are still having pain, ask about a thigh shot.
    *******
    Married Jan. 2014
    Me:36 DH: 39
    TTC since August 2014, Mild PCOS + uterine fibroids
    Myomectomy June 2015- 18 fibroids removed
    IVF #1, May 2016 = 32 eggs retrieved, 12 fertilized, 7 frozen, 3 PGS normal
    FET#2, July 2016 = one embryo transferred 
    TRIGGER
    BFP! Beta = 617
    Due date = 4/9/17
    Delivery date = 3/20/17
  • Options
    I too had some pain during injections but after I stopped I had none after about 2-3 days. 
    About us:
    Me - 28, Lean PCOS
    DH - 31
    Married June 2010, TTC since March 2014
    Blog: ourbinarystar.com

    FET cycle #3 Transfer July 28th 2016, Triplets born healthy on February 26th 2017 at 33w1d!

  • Options
    After a month of injections I suggest:

    1.) Watch a bunch of YouTube videos to make sure you are getting the injection in the right spot. One time my husband was about one inch over from the spot he needed to be and it hurt for days!
    2.) Make sure whoever gives you the injection uses one hand to hold the base of the shot where it enters your skin. This helps avoid the needle jiggling/moving too much and scratching the muscle.
    3.)MASSAGE the injection site for at least 30 seconds afterward and apply a heating pad for 5-10 minutes. This was life changing for me and eliminated all my pain!! 

    Good luck!!
  • Options
    I asked this on another board but I'm having a problem getting the progesterone in ethyl oleate. My usual pharmacy can't ship it right now for some reason. So they sent the Rx to Freedom fertility which only carries progesterone in sesame oil. My doc does not use this. And of course my REs nurses didn't return my calls today. What pharmacies did you ladies use??

    TTC for 8 years.
    Started in 2008 with timed intercourse, ovulation testing, no official monitoring.
    OB-GYN recommended Clomid and timed intercourse, attempted for 6 straight months.
    First surgery June 2009 (OB-GYN): diagnosed with stage 4 endometriosis and large hydrosalpinx on right tube.
    Second surgery (July 2009, RE performed this): Right tube had to be removed, lots of adhesions removed.
    Attempted "trying on our own" as per RE recommendations, unsuccessful 5-6 months.
    HSG performed December 2009: left tube open.
    February 2010: started Femara and timed intercourse, attempted 6 months, no BFPs.
    Took a break for a while.
    January 2011: started IUI process, ovaries never properly responded to medications, 6 failed attempts, never actually completed an IUI.
    Took 2012-2014 off due to depression and frustration (side note: did complete grad school to become a nurse practitioner- great distraction).
    2015: started seeing RE again, went through tons of testing and HSG, left tube now blocked, only option is IVF.
    September 2015: Started first official IVF cycle, cancelled in October due to large cyst on left ovary.
    October 2015: started on birth control for 2 months.
    December 2015: attempted to start another IVF cycle, cysts on both ovaries on initial ultrasound, left was huge, cancelled to aspirated cyst.
    January 2016: Cyst back, surgery for ex-lap, cyst and adhesions removed.
    March 2016: Attempted second IVF cycle, estrogen way too high, cyst back, cancelled again.
    April 2016: Third attempted IVF cycle, 7 eggs retrieved, 2 mature (but not great) embryos made to fresh transfer, neither implanted.
    May-Sept 2016: Break to regain sanity.
    Sept-Oct 2016: Attempted fourth IVF cycle, very successful, cyst still on left but we ignored. 7 mature "great looking" eggs retrieved, 4 mature embryos made it to day 5 transfer. Transfer aborted due to large amount of endometriosis fluid in uterus.
    FET of 2 embryos completed on 12/12/16.
    12/22/16 1st Beta 179 BFP!!!
    12/24/16 2nd Beta 449!!
    EDD 8/30/17 with two girls!!!!!

    Audrey (4lb 8oz) and Olivia (6lb 6oz) born 8/10/17!!

  • Options
    @tiffanyw1783 I answered you in the other thread but wanted to make sure you saw. I got my PIO in ethyl oleate from Lake Country Pharmacy. It is a compounding pharmacy located in GA but they ship overnight. They were really wonderful to deal with. I hope you get the right kind ordered in time! I had a bad reaction to sesame oil with IVF #1, and it was not fun.
    *** Trigger Warnings ***

    TTC #1 since March 2011
    Dx = Unexplained IF
    1 medicated TI cycle & 4 clomid IUIs = all BFNs
    June 2013 IVF #1 = 6 frosties + BFP!
    DS1 born 2/14

    TTC #2 since December 2014
    May 2015 unassisted BFP ended in m/c at 7wks
    April 2016 FET #1 = BFN
    June 2016 FET #2 = c/p
    August 2016 FET #3 = BFP!
    DS2 born 4/17
  • Options
    I use Avella speciality pharmacy. They ship nationally and were the least expensive when I shopped around. 
  • Options
    I have used CVS Specialty Pharmacy which I believe is a compounding pharmacy and Village Pharmacy based out of Waltham, MA for my fertility meds. I have also had meds compounded from Phusion Pharmacy and they do progesterone compounds, though I'm not sure about the exact one you're looking for.
  • Options
    I finally found it at several different pharmacies and my RE has used Avella before so we went with them. Thank you ladies for all the recommendations. I had no idea that all specialty pharmacies that dealt with fertility meds didn't have the Progesterone in ethyl oleate.

    TTC for 8 years.
    Started in 2008 with timed intercourse, ovulation testing, no official monitoring.
    OB-GYN recommended Clomid and timed intercourse, attempted for 6 straight months.
    First surgery June 2009 (OB-GYN): diagnosed with stage 4 endometriosis and large hydrosalpinx on right tube.
    Second surgery (July 2009, RE performed this): Right tube had to be removed, lots of adhesions removed.
    Attempted "trying on our own" as per RE recommendations, unsuccessful 5-6 months.
    HSG performed December 2009: left tube open.
    February 2010: started Femara and timed intercourse, attempted 6 months, no BFPs.
    Took a break for a while.
    January 2011: started IUI process, ovaries never properly responded to medications, 6 failed attempts, never actually completed an IUI.
    Took 2012-2014 off due to depression and frustration (side note: did complete grad school to become a nurse practitioner- great distraction).
    2015: started seeing RE again, went through tons of testing and HSG, left tube now blocked, only option is IVF.
    September 2015: Started first official IVF cycle, cancelled in October due to large cyst on left ovary.
    October 2015: started on birth control for 2 months.
    December 2015: attempted to start another IVF cycle, cysts on both ovaries on initial ultrasound, left was huge, cancelled to aspirated cyst.
    January 2016: Cyst back, surgery for ex-lap, cyst and adhesions removed.
    March 2016: Attempted second IVF cycle, estrogen way too high, cyst back, cancelled again.
    April 2016: Third attempted IVF cycle, 7 eggs retrieved, 2 mature (but not great) embryos made to fresh transfer, neither implanted.
    May-Sept 2016: Break to regain sanity.
    Sept-Oct 2016: Attempted fourth IVF cycle, very successful, cyst still on left but we ignored. 7 mature "great looking" eggs retrieved, 4 mature embryos made it to day 5 transfer. Transfer aborted due to large amount of endometriosis fluid in uterus.
    FET of 2 embryos completed on 12/12/16.
    12/22/16 1st Beta 179 BFP!!!
    12/24/16 2nd Beta 449!!
    EDD 8/30/17 with two girls!!!!!

    Audrey (4lb 8oz) and Olivia (6lb 6oz) born 8/10/17!!

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