Trouble TTC
lablover78
member
Methylation Defects?
lablover78
member
in Trouble TTC
Here is a pretty interesting blog post on a possible cause of various forms of infertility. https://www.thedetoxdiva.com/methylation-defects-and-your-fertility/
I had a 2nd opinion this morning that I'm still trying to digest. He suspects a methylation defect....said he thought I might be intolerant to histimines which could be leading to inflammation which is causing implantation issues. He felt 'a lot more work up' was needed before jumping into IVF. I'm shocked and so happy I randomly booked this. My DH feels the same. He gave me more information in my free consultation than my current RE's office (who I don't have any real complaints of) has done after 4 months and $5k. His approach was almost similar to an NMD- lots of questions about all aspects of my life/health. Was not expecting that at all from his website. Anyway, feeling more positive than I have I awhile!
I had a 2nd opinion this morning that I'm still trying to digest. He suspects a methylation defect....said he thought I might be intolerant to histimines which could be leading to inflammation which is causing implantation issues. He felt 'a lot more work up' was needed before jumping into IVF. I'm shocked and so happy I randomly booked this. My DH feels the same. He gave me more information in my free consultation than my current RE's office (who I don't have any real complaints of) has done after 4 months and $5k. His approach was almost similar to an NMD- lots of questions about all aspects of my life/health. Was not expecting that at all from his website. Anyway, feeling more positive than I have I awhile!
TTC since May 2013
Mild PCOS, Compound Heterozygous MTHFR
No Folic acid/pharmaceuticals/supplements (too many to list- private message me if interested), IVIL infusion
No Folic acid/pharmaceuticals/supplements (too many to list- private message me if interested), IVIL infusion
Re: Methylation Defects?
TTC since 2011
TTC #1 Since: April 2015
Unexplained Infertility
Cycle 1&2 : Clomid 50mg- BFN
Cycle 3: Letrozole 2.5mg- BFN
Cycle 4: Letrozole 5mg- BFN
Cycle 5: HSG-normal
Clomid 100mg+ Estrace- BFN
Cycle 6: Letrozole 5mg+Trigger shot+IUI+Progestrone- BFN
Cycle 7: Letrozole 5mg, Cyst found during follicle check
Cycle 8: Birth control to treat left ovary cyst
Cycle 9: Letrozole 7.5mg+Trigger shot+IUI+Progesterone- BFN
Cycle 10: Letrozole 7.5mg, 2 Cysts found during follicle check
Cycle 11: Clomid 100mg+Estradiol+Trigger shot+IUI+Progesterone- BFN
Cycle 12: Clomid 100mg- BFN
Cycle 13-16: Natural attempts while awaiting IVF
Cycle 14: IVF-BFN
TW:
HSG/FSH/AMH/E2/SA all normal DX: unexplained IF
spontaneous BFP 01/01/2017- Alexander was born sleeping 04/13/2017 at 19w1d ic/chorio
September 2017 HSG #2 & Gonal-F/Femara/Ovidrel/IUI #1 = ep (Salpingectomy of left fallopian tube)
spontaneous BFP 01/02/2018 EDD Aug 30th It's a GIRL!
Cerclage placed on 03/02
MFI (High DNA Fragmentation) & Mild endometriosis
Aug 2016 - May 2017 6 IUI's with letrozole - BFN
April 2017 - laparoscopy to remove mild endo
June 2017 - Mini IVF letrozole 12.5mg, Gonal-F 75IU - Cancelled early ovulation, no eggs retrieved.
Aug/Sept 2017 - Mini IVF letrozole 12.5mg, Gonal-F 75IU, cetrotide - 13 eggs retrieved, 11 mature
5 eggs ICSI'd 6 eggs frozen - 1 day 5 blast transfered, 2 expanded blast frozen - BFP!
May 2018 - Baby girl born - Our Joy
TTC #2 since July 2019
July 2019 - FET - BFN
Jan 2020 - FET - canceled due to family health issues
Mar 2020 - FET - low beta - chemical pregnancy
July 2020 - ICSI'd remaining 6 eggs - 3 fertilized - 2 survived to early blast stage, transfered both - Chemical Pregnancy
DX: PCOS/Unexplained Infertility/MTHFR Mutation
TTC since December 2014
Fresh Transfer: Gonal, Menopur, Cetrotide. ~ Chemical Pregnancy
FET #1: 1st Beta- 3,792~ 2nd Beta- 4,227~ BFP ~ Miscarriage at 8 weeks
FET #2: 1st Beta 207~2nd Beta 235~ BFP~ Miscarriage at 6 weeks
FET #3: 1st Beta 18~ 2nd Beta 44~BFP~ Miscarriage 5 weeks
FET #4: 1st Beta 50~ 2nd Beta 97.7~ Miscarriage 6 weeks 5 days
FET#5: 1st Beta 29~ 2nd Beta 109~ 3rd Beta 227~ 4th Beta 661~ Miscarriage 5 weeks 3 days
Miracle Natural BFP Estimated Due Date June 2019~ God is good
2 snow babies