Third-Party Reproduction

How Do You Feel About PGS?

Talk to me about the pros/cons of PGS. Our first son was born via gestational carrier in May. We did not do any genetic screening. This will be our last child, and the doctor mentioned doing PGS only because of the fear something could go wrong during the pregnancy that we could have prevented. How do you feel about PGS? Is it necessary? I'm 31 and my husband is 34.

Re: How Do You Feel About PGS?

  • I think it could depend on if you are using frozen or fresh embryos and how many you get.

    TTC #1 since 12/2010 DH: MFI, cancer survivor Me: Resected septate uterus, lap treated mild endo, tubes open, ovulate on own, autoimmune disease 3 Failed IUI's (2/2012, 4/2012, 6/2012) 
    IVF #1 August 2012. BFP! Beta #1 56.7 Beta #2 150 One baby, one heartbeat on 9/20/12! no h/b @7w6d. dandc @8w0d
    FET #1 December 2012, BFN
    FET #2 February 2013, no embies survived thaw
    IVF #2, BFP #2, Loss #2 March 2013, Scar tissue discovered, RPL testing,
    IVF #3, BFP #3, Loss #3 (twins) September 2013
    Hostile ute, moving onto Gestational Carrier!

    GC/FET #1 of 1 5AA blast and 1 compacted blast, February 2014, BFP #4 on 3/1/2014!
    6w u/s 1 bean with h/b of 145 bpm, 8w u/s 187 bpm
    EDD 11/7/14. Please, please, please stick little one!

    Praying unceasingly for a miracle. ALL welcome!

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  • We did CCS screening with our embryo that we transferred back in April, mostly because we were asked to be in a study. It was very reassuring to know that we were transferring a chromosomally normal blastocyst, though the outcome of the cycle was negative.
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!
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  • I had 7 losses so I may have different view on things than other people here. I just did my first donor egg cycle. She was only 24. We ended up with only 2 day 5 blastocysts and tested them overnight for day 6 transfer. They both came back euploid - chromosomally normal. The risk of early MC is lowered I believe by 15%. The piece of mind that I had a fair chance with every transfer is priceless. I am also 37 and been in a position when I wasted 3-6 months after MC's for recovery time. If you can afford it I would totally do it. If you are in the sated and on the east coast ask you clinic if they could use IVIGEN. They are fairly inexpensive and you don't have to do a frozen cycle with them.
    TTC since 2007; Unexplained; 8PG: 4CP, 2EP, 2MC w/HB at 8-9 weeks
    Getting ready for DIVF #1 - Transfer 12/16! 
  • I agree with @vibeee. I have a chromosomal issue that affects egg quality. During my first IVF cycle, we had 2 embryos that were graded perfectly, however after PGS testing it showed that they were chromosomally abnormal. Had I transferred them, I would have either ended up with m/c's, stillbirths, or children that would have died shortly after birth. The grading of embryos isn't always a great indicator of how healthy they actually are.

    TTC since April 2012

    BFP #1, 10/03/2012 - EDD 6/15/2013 - MMC 11/15/2012 - D&C 01/04/2013

    BFP #2, 04/06/2013 - EDD 12/17/2013 - MC 04/19/2013

    6/12/2013 Diagnosed with Balanced Translocation (12 & 16)

    IVF #1 with PGS: 10/2013: Canceled 9/27/2013 for issues with genetic lab

    IVF #1.5 with PGS: 11/16/2013: Canceled. 11 eggs retrieved, 9 mature & 9 fertilized, all unhealthy embryos

    IVF #2: 1/22/14: Canceled. 16 eggs retrieved, 14 mature, 7 fertilized, all unhealthy embryos

    IVF #3 with PGS: 5/10/2014: Switched to FET in July. 10 eggs retrieved, 9 mature, 8 fertilized, 2 healthy embryos!

    FET #1: 7/31/2014: Transferred 2 nearly perfect (6AA, 6BA) healthy embryos- BFFN

    Laproscopy: 10/2014: Healthy uterus

    IVF #4: 12/8/2014: Canceled. 17 eggs retrieved, 15 mature, 10 fertilized, all unhealthy embryos



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    Everyone welcome on my posts






  • I think it depends on the circumstances. For our situation, we saw no reason to use it. We had a young donor and no known sperm issues. Once I got pregnant, we also declined all genetic screening. On the other hand, my dear friend had a long history of losses. She could not stay pregnant and ultimately found out that her husband has a rare chromosomal translocation. So for them, it made sense. If they continued to transfer embryos without testing first their chances of repeat losses were so high as to almost be a certainty.
    Baby girl Lila born 2013.
    Baby boy Henry born 2015.
    Expecting our capstone baby (boy) early March 2018.
  • And just to add what I would think is super obvious, gender selection is never a reason for embryo testing. That is profoundly unethical and my clinic refuses to do it.
    Baby girl Lila born 2013.
    Baby boy Henry born 2015.
    Expecting our capstone baby (boy) early March 2018.
  • We did PGD when we cycled with DE and my DH's sperm, because he carries a balanced translocation. 4 were tested, we only had 1 normal. Had we transferred the that were chromosomally abnormal it would have likely ended in m/c, or like jbasore1123 mentioned, stillbirths, or children that would have died shortly after birth.  

    I personally would not do it solely for gender selection.  
    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015


    http://icanhazbabyz.blogspot.com/
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