Pregnant after IF

MTHFR

Any MTHFR ladies out there? If so what mutation of the gene do you have and what is your treatment protocol?

I have c677t heterozygous. Today my RE started me on folgard along with my prenatal and baby aspirin. However whem googling, I keep reading things about lovenox?

Married 12/4/12

Began TTC 11/2012

Diagnosed as anovulatory 7/2013

Round #1 Clomid 50 mg 8/2013= BFN

Round#2 Clomid 50 mg 9/2013=BFN

First appointment with RE 9/27/2013

HSG showed left tube completely blocked, diagnosed with hypothyroid and began 50 mcg Synthroid, Vitamin D level low and began 2000 iu Vitamin D, Hubby's SA showed "super sperm" according to RE

Round#3 Clomid 50 mg + Ovidrel trigger 10/2013= BFN

Round #4 Clomid 50 mg + Ovidrel trigger 11/2013=BFN

Round #5 Clomid 50 mg (no trigger, on vacation) 12/2012= BFN

Round #1 Femara 2.5 mg, no trigger, IUI cancelled due to early ovulation 1/2014= BFN

1/25/2014= BENCHED for the first time (two leftover follies on the right)

2/7/14 Diagnosed with MTHFR/Benched

4/2014 Round #2 Femara 5mg, IUI #1=BFN

4/28/14 positive opk with no treatment while on break, confirmed with ultrasound= BFN

5/16/14 5mg Femara + trigger + TI=  BFN

6/2014 5mg Femara + trigger + TI= BFN

Awaiting IVF consultation appointment on 7/29/2014

8/8/14 Began BCP's to prep for IVF

9/16/14 Began Lupron injections

9/25/14 Began stimming for IVF #1 with Menopur and Bravelle

10/8/14 10 eggs retrieved

10/13/14 2 embryos transferred

10/21/14 BFP!!!

11/24/14 confirmed that baby stopped growing at 6 weeks, d&c scheduled 




Re: MTHFR

  • I'm homozygous c677t. I was on BA, lovenox and Neevo. 2 copies is worse than one copy so you may not need lovenox. I had 2 prior m/c (non doubling betas) and this last cycle was my first on lovenox.

    I know lots of REs prescribe folgard but giving a higher dosage of folic acid which your body can't properly convert isn't the best treatment. Neevo or Metanx contain methylated folate so there's nothing to be converted. Thorne prenatals on Amazon (no script needed) contain methylated folate.

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

  • FishyMomFishyMom member
    edited October 2014
    I am heterozygous c677t. My RE put me on Folgard and I did nothing else. No aspirin no lovnox. I just took the pills and still do.

    I should also add I don't honestly think it effected anything bad or good. I received the diagnosis after my MC, but the RE and I both think that is not at all what caused it.

    Good luck!!
    ******************** BFP Warning *******************
     
    I'm 29 and DH is 32 we have a MFI (low count) 
    IVF #1 starting in August. ER 9/5/13 23 eggs we are fertilizing 15. 9 frozen
    ET 9/10 - transferred 1 perfect 5AA blast
    7dp5dt BFP ~~ Beta on 9/19 - 77.4 Beta #2 on 9/21 - 357
    Low heartbeat on 10/7 86, lower heartbeat on 10/11 76, no heartbeat 10/14/13. D&C 10/15/13
    Tests revealed MTHFR c677t mutation, put on Folgard.
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    FET #1 1/6/14 - 4BB blast - BFN
    FET #2 - 3/3/14 - 5AB Blast -- Beta #1 3/12 - 152 -- Beta #2 3/14 - 358
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    FET #3 06/09/16 - 5AB Blast - Beta #1 6/18- 245 -- Beta #2 06/20 - 600
     PAIF/SAIF/PAL/SAL welcome!

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  • I am hetero c677t, too, and take an extra 2mg folic acid and baby aspirin. My RE also did not think it was the cause of our issues, but I'll do whatever he says. Lots of luck!
    **Signature Warning**

    Dx PCOS August 2012
    Clomid x4 = BFN
    Femara+Follistim IUIs x 6 = 3 BFN, 2 C/P, 1 early miscarriage
    IVF June 2014- 43 R, 34 M, 24 F, 12 blasts frozen and severe OHSS
    FET September 12, 2014!
    Beta #1 12dp5dt- 724
    Beta #2 14dp5dt- 1631
    Beta #3 20dp5dt- 12,813
    Pending EDD at first OB appointment 11/6. Grow babies grow!

    "I might have to wait. I'll never give up. I guess it's half timing, and the other half's luck. 
    Wherever you are, whenever it's right, you'll come out of nowhere and into my life." ~ Michael Buble

    image


  • The user and all related content has been deleted.
  • I am heterozygous c677t and I take methofolate and baby aspirin. 
    ***siggy/ticker warning***

    Me:36 DH:38 TTC#1 since 4/2012
    Me DX: Hashimotos,Hypothyroid, DOR, MTHFR,  DH: normal

     IUI #1-#4 BFNs and a few cancelled cycles in the mix.
    - poor responder
    ***Suprise BFP on 6/13/13. Natural MC @6wks 3days
    IVF#1 and 2- Cancelled due to no response on max stimms
    FET 5/20- BFP
    1st Beta- 641
    2nd beta- 2166
    Sono- TWINS!!!!
    Two Boys! Born January 2015 @36 weeks.  Healthy and no NICU!  So blessed!



    image 

  • I have a single mutation and my OB said just a baby aspirin is fine to address it. I'm also on Lovenox but that's because I have high anti-phospholipids
    Our Novel of TTC:

    *Male Factor (low count and low motility), High Prolactin, and Polycystic Ovaries (March 2013)
    *Recurrent Miscarriage testing also revealed high anti-phospholipids & single MTHFR mutation. (Feb 2014) 

    *IVF (07/2013): BFP-Natural Miscarriage @ 5 weeks* <3 Madison Riley <3
    *FET #1 (10/2013): BFN
    *FET #2 (12/2013)- BFP-Missed Miscarriage at 8 weeks <3 Kyle Andrew <3
    *Chromosomes and Karotyping tests were both normal.We lost a healthy baby boy :(
    *FET #3 (04/2014) was cancelled after finding Chronic Endometritis
    *Miraculous BFP July 2014!! (I was taking baby aspirin and Cabergoline to stay regulated while "taking a break from TTC" and waiting to consult with a reproductive immunologist!!!) 

    Our healthy baby girl was born 03/10/15 thanks to daily Lovenox injections and baby aspirin. There are no words for how grateful I am for our rainbow baby. <3
  • Thanks ladies, I was hesitant to take the folgard after doing some research but after talking to my doctor this morning I feel much better about my medication plan.

    Married 12/4/12

    Began TTC 11/2012

    Diagnosed as anovulatory 7/2013

    Round #1 Clomid 50 mg 8/2013= BFN

    Round#2 Clomid 50 mg 9/2013=BFN

    First appointment with RE 9/27/2013

    HSG showed left tube completely blocked, diagnosed with hypothyroid and began 50 mcg Synthroid, Vitamin D level low and began 2000 iu Vitamin D, Hubby's SA showed "super sperm" according to RE

    Round#3 Clomid 50 mg + Ovidrel trigger 10/2013= BFN

    Round #4 Clomid 50 mg + Ovidrel trigger 11/2013=BFN

    Round #5 Clomid 50 mg (no trigger, on vacation) 12/2012= BFN

    Round #1 Femara 2.5 mg, no trigger, IUI cancelled due to early ovulation 1/2014= BFN

    1/25/2014= BENCHED for the first time (two leftover follies on the right)

    2/7/14 Diagnosed with MTHFR/Benched

    4/2014 Round #2 Femara 5mg, IUI #1=BFN

    4/28/14 positive opk with no treatment while on break, confirmed with ultrasound= BFN

    5/16/14 5mg Femara + trigger + TI=  BFN

    6/2014 5mg Femara + trigger + TI= BFN

    Awaiting IVF consultation appointment on 7/29/2014

    8/8/14 Began BCP's to prep for IVF

    9/16/14 Began Lupron injections

    9/25/14 Began stimming for IVF #1 with Menopur and Bravelle

    10/8/14 10 eggs retrieved

    10/13/14 2 embryos transferred

    10/21/14 BFP!!!

    11/24/14 confirmed that baby stopped growing at 6 weeks, d&c scheduled 




  • I have compound hetero (one of each). I met with two REs, an OB and an MFM to discuss this diagnosis and all said adding an injection blood thinner was overkill. I'm currently on Metanx and baby aspirin and 28 weeks pregnant with twins. Something must be working.

    Best of luck to you.
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