Oh dear. It's here.

airidh80

The Lupron rage has arrived. Dear Lord, please give me the strength to not cut some bitches today.

How do you manage your Lupron-induced pissiness? I find it helps to go out for walks when I can, and look at pictures of bunnies when I cannot.

Twinkie0612

I pretty much tell people to stay the fuck away from me. It's good advice.

airidh80

I did 6 months of depot when I was 20, after my first laparoscopy. It was... bad. Really bad. It actually ruined me for over year. I have since refused every exhortation from every RE to go back onto depot. I only agreed to standard FET protocol under duress. That said, I had an unusually bad reaction to it, and most people do much better than I did. 

But yeah. Even in small doses, it is like injectable rage. I told my husband it's like 0-60 in 4.2 seconds on the anger scale. Everything is totally fine, and then someone does something *slightly* irritating, and it's like, KILL ALL THE THINGS RAWWWWRRR.

airidh80

I guess I was lucky in a way, because I had prior experience with Lupron and I knew exactly what it was going to do to me, so I was able to sit DH down ahead of time and say, "Listen, I'm about to become a total monster. I promise I will always do my best to recognize when I'm being unreasonable and control my response, but you also need to understand that my temper will be hair-trigger, and I won't be able to handle our usual verbal sparring. And also sometimes I might just need to sit and stew in my own rage, or go out for a walk, and that doesn't mean I hate you, it just means I'm angry and need to deal with it in my own way."

airidh80

Mine started after two doses of 10 units. Maybe you'll get lucky, and you won't notice it as much. 

Pintobean39

I'm on my 4th week of 20 units. I can feel the anger building up in me, even in my sleep. I don't like anyone right now. My husband came home from work today and literally changed out of his dress clothes and put his scrubs on and turned around and went back to work. He normally spends about 3-4 hours at home during the day on his long days so we can at least see each other. He would rather work 15 hrs than spend a minute with me. I can't blame him, I'm bad, but I still cried like a baby when he left. I HATE this stuff!!!

airidh80

@pintobean39, Lupron makes it really difficult for me to sleep, too. It's hard to unclench. Your mind just keeps going, pumping out tense and angry thoughts. Or, if you're like me, you start replaying every mistake you've ever made, over and over, for hours.

I feel like every Lupron prescription should come with one Xanax, every day, to be taken at bedtime.

(edited to correct tag)

Pintobean39

airidh80 said:

@pintobean, Lupron makes it really difficult for me to sleep, too. It's hard to unclench. Your mind just keeps going, pumping out tense and angry thoughts. Or, if you're like me, you start replaying every mistake you've ever made, over and over, for hours.

I feel like every Lupron prescription should come with one Xanax, every day, to be taken at bedtime.

I take baclofen and 12.5 mg of Benadryl at night before bed so they kinda make me sleepy, so sleeping isn't my problem. It's the daytime I'm struggling with. I seriously thought about taking a nibble of some Xanax today, I'm just so worked up, I feel it in my chest. I'm almost finished my second bottle of my 2 week kit and I have to order another bottle because I have 2-3 more weeks of this.

I have noticed I'm having very vivid dreams. I was so convinced the other night someone was coming to break in my house, so I got up set the house alarm and didn't tell my husband. Needless to say when he got up to go to work before I got up he opened the door and set the alarm off. I'm getting scared to sleep because the nightmares are so bad. Is this just me? They started on my second week of this devil drug.

airidh80

I don't have vivid dreams while on Lupron, but I've heard that other people do. 

I find it difficult to keep it together during the day, too. It's hard not to snap at people. Have you ever read Tina Fey's Bossypants? She describes this feeling of intense stress and desperation as a "heart raisin." That's kind of what I feel like... I have a heart raisin. But's it's also a stomach raisin and a jaw raisin and a scalp raisin, too.

kittenmittens9

oh no!  No one told me there would be even more rage with Lupron.  I've never taken it before and I start it next week.  

@airidh80:  I already sit in bed a lot of nights over thinking my mistakes from the day at baseline. So I'll be in a rage from the meds and from not sleeping?  

pblge

Gack, so sorry ladies. I do feel the need to comment here, for the benefit of the newbies, that lots of women don't have these problems on Lupron. I never had headaches moodiness or any other negative side effects. (I get all that on BCP, though.) Sorry, I'm not trying to gloat, but I don't want new folks to be terrified! Also, I think the Lupron depot is a much higher dose, right?

On the other hand, the hubbies don't know better, so if this is a good excuse, let your b!tch flag fly!!!

airidh80

Yes, depot is a much higher dose that stays in your system much longer. I'm not using depot, but like I said, I have an unusually strong reaction to Lupron.

@kittenmittens9, you might be totally fine. Everyone reacts to different drugs in different ways. And if you do get the anxiety/rage, you'll get through it. We all do, in the end

kittenmittens9

@airidh80, thanks.  I just hope I don't get too crazy, for DH's sake

airidh80

Try not to worry about it until you have to. Everyone is different. FX that you (and everyone else reading this!) cruises through Lupron with no problems at all!

starlightgator

OMG! I had no idea Lupron was going to turn me into a raging bitch. Holy Crap! I'm starting teacher week back next Wednesday and kids arrive on the 20th. I'm supposed to start Lupron with IVF#2 in the first week of September. My nurse told me that it's called a micro dose. I hope that means it won't be as bad. When I stimmed on Gonal F and Menopur last time (we only had 3 days of Ganirelix at the end), I didn't really feel too many crazy emotions except once or twice crying fits. Now, I am really worried because I'll be taking it along with stims for the whole 10-12 days. YIKES!

Does anyone understand what Lupron will do to help the cycle? It's all new to me.

airidh80

How my doctor explained it to me is, Lupron temporarily stops estrogen production in women (or, interestingly, testosterone production in men.) But during the first few days of the drug, your pituitary "flares" and releases larger doses of FSH and LH. After that initial flare up, which is usually about 3 days, your pituitary is suppressed and produces very little FSH or LH. So usually, you would start start your stim drugs on Day 3. 

I don't know exactly what protocol you're using, but that's the basic idea - you stimulate a natural surge from your own pituitary, and then allow the stim drugs to take over. It can be very helpful for improving response in poor responders.

I feel bad that everyone who hasn't start lupron is freaking out now! Anger/agitation/stress are common side effects of Lupron, but not everyone experiences them, and even those who do have varying levels of anger/stress/irritation.

So you know that phrase, "Don't trouble trouble 'til trouble troubles you?" Replace that with, "Don't trouble Lupron 'til Lupron troubles you." 

airidh80

And one more thing: If you do get the Lupron Crazies, I find it helpful to constantly ask myself, "Is this a reasonable reaction/response, or is this the drug talking? What am I really feeling here?" Take lots of deep breaths. Make an effort to get some exercise, it can help reduce the agitation. And don't be afraid to ask your partner for some alone time.

jencity9

I actually am one of the ones who had no side effects with Lupron! One of the nurses suggested maybe it was because my hormones were already out of whack from PCOS, lol... Who knows. When I took Letrozole I had headaches and some moodiness.

airidh80

Meanwhile, I just found a desiccated shrimp under the couch, and my Lupron-rage has me seriously debating how much I actually love my husband.